NF-κB
Catalog No. | Inhibitor Name | NF-κB | Other |
---|---|---|---|
A12748 | QNZ (EVP4593) | **** | TNF-α |
A14142 | JSH-23 | ** | |
A14278 | SC75741 | *** | |
A13698 | Caffeic Acid Phenethyl Ester | ||
A10077 | Andrographolide | ||
A15046 | CID-2858522 | *** | |
A16301 | (+)-DHMEQ | ||
A16302 | (-)-DHMEQ | ||
A16306 | Pyrrolidinedithiocarbamate ammonium | ||
A10698 | Parthenolide | p53,MDM2 ubiquitination,HDAC1 |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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SC75741
Catalog No. A14278 -
CID-2858522
Catalog No. A15046 NF-κB 抑制剂CID-2858522选择性抑制由PKC诱导的NF-κB途径 (对于PMA刺激的IL-8产生IC50 <0.1 uM),在PKC下游但在IKKbeta上游起作用,而没有抑制其他NF-κB激活途径。 了解更多 -
Pyrrolidinedithiocarbamate ammonium
Catalog No. A16306 NF-kB 抑制剂Pyrrolidinedithiocarbamate ammonium是一种选择性的NF-kB抑制剂,可抑制一氧化氮合酶mRNA的翻译以防止诱导。 了解更多 -
Andrographolide
Catalog No. A10077 Apoptosis InducerAndrographolide是具有抗癌和免疫调节活性的令人感兴趣的药效团,因此具有被开发为癌症治疗剂的潜力。 了解更多 -
Parthenolide ((-)-Parthenolide)
Catalog No. A10698 Parthenolide ((-)-Parthenolide), Nuclear Factor-κB抑制剂,可特异性地耗尽HDAC1蛋白,而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。 了解更多 -
QNZ (EVP4593)
Catalog No. A12748 -
Caffeic Acid Phenethyl Ester
Catalog No. A13698 NF-κB activation 抑制剂Caffeic Acid Phenethyl Ester是一种有效且特异性的NF-κB活化抑制剂。 了解更多 -
Dehydrocostus Lactone
Catalog No. A14809 Dehydrocostus Lactone通过阻止TNF-α诱导的降解和磷酸化来抑制NFκB的活化。 了解更多 -
Tomatidine
Catalog No. A16233