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Nilotinib monohydrochloride monohydrate是一种Bcr-Abl抑制剂，IC50小于30 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.12 mL | 85.62 mL | 171.24 mL |
| 0.5 mM | 3.42 mL | 17.12 mL | 34.25 mL |
| 1 mM | 1.71 mL | 8.56 mL | 17.12 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
*The above data is based on the productmolecular weight 583.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15186 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 583.99 |
| Formula | C28H25ClF3N7O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 923288-90-8 |
| Synonyms | AMN-107, Tasigna, AMN107 |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5.O.Cl |
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