Ningetinib
目录号: A17042
tyrosine kinase 抑制剂
Ningetinib 是一种多激酶抑制剂，能够抑制 c-Met、VEGFR2/KDR 和 Axl，其 IC50 值分别为 19、37 和 11 nM。
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生物活性
| Discription | Ningetinib is a multi-kinase inhibitor that inhibits c-Met, VEGFR2/KDR, and Axl with IC50s value of 19, 37, and 11 nM, respectively. | ||
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| Targets |
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产品信息
| 目录号 | A17042 |
|---|---|
| 分子式 | C31H29FN4O5 |
| 分子量 | 556.6 |
| CAS号 | 1394820-69-9 |
| SMILES | FC1=CC(NC(C2=C(C)N(C)N(C3=CC=CC=C3)C2=O)=O)=CC=C1OC4=CC=NC5=C4C=CC(OCC(O)(C)C)=C5 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 18 mg/mL (32.34 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.97 mL | 89.83 mL | 179.66 mL |
| 0.5 mM | 3.59 mL | 17.97 mL | 35.93 mL |
| 1 mM | 1.8 mL | 8.98 mL | 17.97 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.59 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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