Niraparib tosylate
Niraparib tosylate (MK-4827 tosylate) 是一种高效且可口服吸收的 PARP1 和 PARP2 抑制剂,其 IC50 分别为 3.8 nM 和 2.1 nM。
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重要通知:仅供研究使用。我们不向患者销售。
重要通知:仅供研究使用。我们不向患者销售。
Discription | Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. | ||
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Targets |
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目录号 | A16618 |
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分子式 | C26H28N4O4S |
分子量 | 492.59 |
CAS号 | 1038915-73-9 |
SMILES | NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O.O=S(C5=CC=C(C)C=C5)(O)=O |
其他名称 | MK-4827 tosylate |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 86 mg/mL (174.58 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 20.3 mL | 101.5 mL | 203.01 mL |
0.5 mM | 4.06 mL | 20.3 mL | 40.6 mL |
1 mM | 2.03 mL | 10.15 mL | 20.3 mL |
5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2