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NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.59 mL | 142.94 mL | 285.89 mL |
| 0.5 mM | 5.72 mL | 28.59 mL | 57.18 mL |
| 1 mM | 2.86 mL | 14.29 mL | 28.59 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.72 mL |
*The above data is based on the productmolecular weight 349.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21965 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 349.79 |
| Formula | C15H12ClN3O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1449236-96-7 |
| Synonyms | NMS 859, NMS859 |
| SMILES | O=S1(C2=CC=CC=C2C(NC3=CC(NC(CCl)=O)=CC=C3)=N1)=O |
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