NPS-2143 (SB-262470)

Name: NPS-2143 (SB-262470)
SKU: A11140
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A11140

CaSR antagonist

NPS-2143 是一种选择性的 Ca2+ 感应受体拮抗剂，已显示能够阻断在 HEK293 细胞中表达的人类 Ca2+ 受体 诱导的细胞质 Ca2+ 浓度 增加，其 IC50 为 43 nM。

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Grouped product items
规格	价格	库存
5mg	¥280.00	现货
10mg	¥490.00	现货
25mg	¥1,050.00	现货
50mg	¥1,575.00	现货
100mg	¥2,380.00	现货
200mg	¥4,060.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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Data Sheet

SDS

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生物活性

Discription

NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11140
分子式	C24H25ClN2O2
分子量	408.9
CAS号	284035-33-2
SMILES	CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O
其他名称	NPS2143, SB262470
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	79 mg/mL (193.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.46 mL	122.28 mL	244.56 mL
0.5 mM	4.89 mL	24.46 mL	48.91 mL
1 mM	2.45 mL	12.23 mL	24.46 mL
5 mM	0.49 mL	2.45 mL	4.89 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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