NS-398
目录号: A13116
COX-2 抑制剂?€?
NS-398 是一种非甾体抗炎药物，具有镇痛和解热效果，能够选择性地抑制前列腺素G/H合成酶2/环氧合酶2（COX-2）活性，其半抑制浓度（IC50）为3.8微摩尔，而在100微摩尔的浓度下对环氧合酶1（COX-1）无影响。
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生物活性
| Discription | NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. | |||||
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产品信息
| 目录号 | A13116 |
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| 分子式 | C13H18N2O5S |
| 分子量 | 314.36 |
| CAS号 | 123653-11-2 |
| SMILES | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2 |
| 其他名称 | NS398, NS 398 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 53 mg/mL (168.59 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.81 mL | 159.05 mL | 318.11 mL |
| 0.5 mM | 6.36 mL | 31.81 mL | 63.62 mL |
| 1 mM | 3.18 mL | 15.91 mL | 31.81 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 123653-11-2 | 123653-11-2 供应商 | 123653-11-2 花费 | 123653-11-2 生产商 | 订购 123653-11-2 | 123653-11-2 代理商