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NSC-207895 (XI-006)是细胞可渗透的苯并呋喃化合物，可通过抑制MDMX启动子转录活性（IC50 = 2.5 ?M，下调MCF-7，LNCaP和A549细胞中的p53负调节剂MDMX蛋白水平（1至10 ?M，持续16至24 h）），导致增强的p53稳定和激活。
靶点信息
| p53 | MDMX | |||
| N/A | 2.5 μM |
| In vitro | DMSO | 0.39 mg/mL (1.39 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.81 mL | 179.05 mL | 358.1 mL |
| 0.5 mM | 7.16 mL | 35.81 mL | 71.62 mL |
| 1 mM | 3.58 mL | 17.91 mL | 35.81 mL |
| 5 mM | 0.72 mL | 3.58 mL | 7.16 mL |
*The above data is based on the productmolecular weight 279.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11179 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 279.25 |
| Formula | C11H13N5O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 58131-57-0 |
| Synonyms | NSC207895 |
| SMILES | CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-] |
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