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NSC-703786 (5F-203) is a cytotoxic molecule that forms DNA adducts leading to cell death. NSC-703786 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. Treatment of cells with NSC-703786 also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 38.71 mL | 193.57 mL | 387.15 mL |
| 0.5 mM | 7.74 mL | 38.71 mL | 77.43 mL |
| 1 mM | 3.87 mL | 19.36 mL | 38.71 mL |
| 5 mM | 0.77 mL | 3.87 mL | 7.74 mL |
*The above data is based on the productmolecular weight 258.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22708 |
|---|---|
| M. Wt | 258.3 |
| Formula | C14H11FN2S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 260443-89-8 |
| Synonyms | 5-fluoro 203, NSC703786, NSC 703786 |
| SMILES | FC1=CC=C(SC(C2=CC=C(N)C(C)=C2)=N3)C3=C1 |
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