NSC59984

Name: NSC59984
SKU: A13413
Price: 385 CNY
Rating: 5 (288 reviews)

目录号: A13413

P53 Activator

NSC59984 通过 MDM2 和泛素-蛋白酶体途径诱导突变型 p53 蛋白的降解。在大多数癌细胞中，NSC59984 的 EC50 显著低于正常细胞，p53 缺失的 HCT116 细胞的 EC50 为 8.38 uM。

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Grouped product items
规格	价格	库存
5mg	¥385.00	现货
10mg	¥700.00	现货
25mg	¥1,540.00	现货
50mg	¥2,555.00	现货
100mg	¥4,130.00	现货
250mg	¥6,965.00	现货
500mg	¥8,785.00	现货
*10mM 1mL in DMSO**	¥455.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription

NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.

Targets

Target	Value

产品信息

目录号	A13413
分子式	C12H15N3O4
分子量	265.27
CAS号	803647-40-7
SMILES	CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-]
其他名称	NSC 59984, NSC-59984
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	48 mg/mL (180.94 mM)
	Water	Insoluble
	Ethanol	48 mg/mL (180.94 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.7 mL	188.49 mL	376.97 mL
0.5 mM	7.54 mL	37.7 mL	75.39 mL
1 mM	3.77 mL	18.85 mL	37.7 mL
5 mM	0.75 mL	3.77 mL	7.54 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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