微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
NSC59984通过MDM2和泛素蛋白酶体途径诱导突变p53蛋白降解。大多数癌细胞中NSC59984的EC50明显低于正常细胞，p53-null HCT116细胞的EC50为8.38 uM。
靶点信息
| p53 | ||||
| In vitro | DMSO | 48 mg/mL (180.94 mM) | |
| Water | Insoluble | ||
| Ethanol | 48 mg/mL (180.94 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.7 mL | 188.49 mL | 376.97 mL |
| 0.5 mM | 7.54 mL | 37.7 mL | 75.39 mL |
| 1 mM | 3.77 mL | 18.85 mL | 37.7 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
*The above data is based on the productmolecular weight 265.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13413 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 265.27 |
| Formula | C12H15N3O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 803647-40-7 |
| Synonyms | NSC 59984, NSC-59984 |
| SMILES | CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-] |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
Pifithrin-alpha
Pifithrin-alpha是p53介导的细胞凋亡和p53依赖性基因转录（如细胞周期蛋白G，p21/waf1和mdm2表达）的可逆抑制剂…
p53 and MDM2 proteins-interaction-inhibitor chiral
p53和MDM2蛋白相互作用抑制剂手性是p53和MDM2蛋白之间相互作用的抑制剂。
RITA (NSC 652287)
RITA，也称为NSC 652287，是一种三环噻吩衍生物，与MDM2结合，破坏MDM2-p53复合物，随后激活p53，并诱导凋亡。
RETRA hydrochloride
RETRA hydrochloride是一种抗肿瘤剂，在体内外均以突变的p53和p73依赖性方式抑制肿瘤细胞的生长。
NSC 319726
NSC 319726是突变体p53R175的有效和选择性激活剂。
NSC 146109 hydrochloride
NSC 146109 hydrochloride是激活p53依赖性转录的细胞渗透性，基因型选择性抗肿瘤剂。
Keywords:购买 NSC59984 | NSC59984 供应商 | 订购 NSC59984 | NSC59984 价格 | NSC59984 生产商 | 订单 NSC59984 | NSC59984 代理商 | 购买 803647-40-7| 803647-40-7 供应商 | 订购 803647-40-7 | 803647-40-7 价格 | 803647-40-7 生产商 | 订单 803647-40-7 | 803647-40-7 代理商|buy NSC59984 | NSC59984 Supplier | purchase NSC59984 | NSC59984 cost | NSC59984 manufacturer | order NSC59984 | NSC59984 distributor | buy 803647-40-7| 803647-40-7 Supplier | purchase 803647-40-7 | 803647-40-7 cost | 803647-40-7 manufacturer | order 803647-40-7 | 803647-40-7 distributor