Nutlin 3a
Nutlin 3a 是一种强效的 MDM2 (mouse double minute 2) 抑制剂，它能阻止 MDM2 与 p53 的结合，从而诱导 p53 调控基因的表达，并在表达功能性 p53 的细胞中显示出强大的抗增殖活性。
顾客使用 Adooq 产品发表的高质量科研文献
Adooq用户使用Nutlin 3a发表的3篇文献
生物活性
| Discription | Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. | |||||
|---|---|---|---|---|---|---|
| Targets |
|
|||||
| Cell Research |
|
产品信息
| 目录号 | A11501 |
|---|---|
| 分子式 | C30H30Cl2N4O4 |
| 分子量 | 581.49 |
| CAS号 | 675576-98-4 |
| SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
| 其他名称 | Nutlin-3a, (-)-Nutlin-3 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 98 mg/mL (168.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 98 mg/mL | ||
| In vivo | 5% DMSO+55% PEG 300+ddH2O | 7 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.2 mL | 85.99 mL | 171.97 mL |
| 0.5 mM | 3.44 mL | 17.2 mL | 34.39 mL |
| 1 mM | 1.72 mL | 8.6 mL | 17.2 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
Keywords: 购买 Nutlin 3a | Nutlin 3a 供应商 | Nutlin 3a 花费 | Nutlin 3a 生产商 | 订购 Nutlin 3a | Nutlin 3a 代理商
| 购买 675576-98-4 | 675576-98-4 供应商 | 675576-98-4 花费 | 675576-98-4 生产商 | 订购 675576-98-4 | 675576-98-4 代理商