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NVP-BGJ398 phosphate是一种新型的选择性泛特异性FGFR抑制剂，对FGFR1，FGFR2和FGFR3的IC50分别为0.9、1.4和1 nM。与FGFR4和VEGFR2相比，对FGFR具有40倍以上的选择性，并且对Abl，Fyn，Kit，Lck，Lyn和Yes的活性很小。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.19 mL | 75.93 mL | 151.87 mL |
| 0.5 mM | 3.04 mL | 15.19 mL | 30.37 mL |
| 1 mM | 1.52 mL | 7.59 mL | 15.19 mL |
| 5 mM | 0.3 mL | 1.52 mL | 3.04 mL |
*The above data is based on the productmolecular weight 658.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15194 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 658.47 |
| Formula | C26H34Cl2N7O7P |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1310746-10-1 |
| Synonyms | BGJ-398 phosphate, BGJ 398 phosphate, NVP BGJ398 phosphate |
| SMILES | CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl.OP(=O)(O)O |
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