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NVP-BSK805 dihydrochloride

NVP-BSK805 dihydrochloride

Name: NVP-BSK805 dihydrochloride
SKU: A21406

目录号: A21406

JAK2 inhibitor

NVP-BSK805 dihydrochloride Chemical Structure

CAS NO. 1942919-79-0

NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.

库存：现货

规格	价格	数量
5 mg	￥ 1,057.00
10 mg	￥ 1,820.00
50 mg	￥ 5,411.00
100 mg	￥ 10,822.00

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产品详情

生物活性

溶解度 *

In vitro (25°C)	DMSO	104 mg/mL (184.57 mM)
	Water	3 mg/mL (5.32 mM)
	Ethanol	14 mg/mL (24.85 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.75 mL	88.74 mL	177.47 mL
0.5 mM	3.55 mL	17.75 mL	35.49 mL
1 mM	1.77 mL	8.87 mL	17.75 mL
5 mM	0.35 mL	1.77 mL	3.55 mL

*The above data is based on the productmolecular weight 563.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A21406
作用机制	Inhibitor (抑制剂)
M. Wt	563.47
Formula	C27H30Cl2F2N6O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1942919-79-0
Synonyms	BSK805 dihydrochloride, BSK 805, BSK-805
SMILES	FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1.Cl.Cl