Signaling Pathway
重要通知：仅供研究使用。我们不向患者销售。
| Discription | NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively. | ||
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| Targets |
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| 目录号 | A21406 |
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| 分子式 | C27H30Cl2F2N6O |
| 分子量 | 563.47 |
| CAS号 | 1942919-79-0 |
| SMILES | FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1.Cl.Cl |
| 其他名称 | BSK805 dihydrochloride, BSK 805, BSK-805 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 104 mg/mL (184.57 mM) | |
| Water | 3 mg/mL (5.32 mM) | ||
| Ethanol | 14 mg/mL (24.85 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.75 mL | 88.74 mL | 177.47 mL |
| 0.5 mM | 3.55 mL | 17.75 mL | 35.49 mL |
| 1 mM | 1.77 mL | 8.87 mL | 17.75 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
