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NVP-BSK805是喹喔啉JAK2抑制剂对红细胞增多症的有效和选择性抑制，喹喔啉JAK2抑制剂可有效抑制小鼠和大鼠中重组人促红细胞生成素诱导的红细胞增多症和髓外红细胞生成。IC50为0.5 nM，比作用于JAK1， JAK3和TYK2选择性高20倍以上。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.75 mL | 88.74 mL | 177.47 mL |
| 0.5 mM | 3.55 mL | 17.75 mL | 35.49 mL |
| 1 mM | 1.77 mL | 8.87 mL | 17.75 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
*The above data is based on the productmolecular weight 563.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11193 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 563.47 |
| Formula | C27H28F2N6O.2HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1092499-93-8 |
| Synonyms | NVPBSK805 |
| SMILES | C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl |
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