NVP-TAE 226

Name: NVP-TAE 226
SKU: A11507
Price: 245 CNY
Rating: 5 (1 reviews)

目录号: A11507

FAK 抑制剂

1 篇发表文献

NVP-TAE226 是一种强效的 FAK 抑制剂，IC50 为 5.5 nM，对 Pyk2 也有适度的抑制作用（IC50=3.5 nM）；对 InsR、IGF-1R、ALK 和 c-Met 的抑制作用较弱，低 10 到 100 倍。

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Grouped product items
规格	价格	库存
1mg	¥245.00	现货
2mg	¥350.00	现货
5mg	¥665.00	现货
10mg	¥1,120.00	现货
25mg	¥1,890.00	现货
50mg	¥2,730.00	现货
100mg	¥4,130.00	现货
*10mM 1mL in DMSO**	¥665.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用NVP-TAE 226发表的1篇文献

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

生物活性

Discription

NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11507
分子式	C23H25ClN6O3
分子量	468.94
CAS号	761437-28-9
SMILES	CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC
其他名称	TAE226, TAE 226
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	93 mg/mL (198.32 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.32 mL	106.62 mL	213.25 mL
0.5 mM	4.26 mL	21.32 mL	42.65 mL
1 mM	2.13 mL	10.66 mL	21.32 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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