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NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.4 mL | 82 mL | 163.99 mL |
| 0.5 mM | 3.28 mL | 16.4 mL | 32.8 mL |
| 1 mM | 1.64 mL | 8.2 mL | 16.4 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.28 mL |
*The above data is based on the productmolecular weight 609.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18771 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 609.78 |
| Formula | C35H39N5O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1454925-59-7 |
| Synonyms | NXT 629, NXT-629 |
| SMILES | O=S(C1=CC=CC=C1)(NC2=CC=C(C3=CC=C(CCCC(N4CC)=NN(CC5=CC=C(C(C)(C)C)C=C5)C4=O)C=C3)N=C2)=O |
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