Obatoclax mesylate (GX15-070)

Name: Obatoclax mesylate (GX15-070)
SKU: A10665
Price: 245 CNY
Rating: 5 (4 reviews)

目录号: A10665

Bcl-2 抑制剂

4 篇发表文献

Bcl-2同源结构域-3（BH3）拟态剂，可拮抗所有抗凋亡的Bcl-2家族蛋白（平均IC50为3微摩尔/升），包括Mcl-1（IC50为2.9微摩尔/升）和Bfl-1（IC50为5微摩尔/升）。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥420.00	现货
25mg	¥840.00	现货
50mg	¥1,540.00	现货
100mg	¥2,590.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Obatoclax mesylate (GX15-070)发表的4篇文献

Ashlyn Parkhurst, .et al. , Cell Death Dis, 2022, Apr 28;13(4):410 PMID: 35484114

Silva S, .et al. , Sci Rep, 2019, Nov 27;9(1):17703 PMID: 31776405

Chi-Hung R. Or, .et al. , Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994

P Geserick, .et al. , Cell Death Dis., 2014, 5(9): e1412 PMID: 25210795

生物活性

Discription

Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).

Targets

Target	Value

产品信息

目录号	A10665
分子式	C20H19N3O.CH4O3S
分子量	413.5
CAS号	803712-79-0
SMILES	CC1=CC(=C(N1)/C=C/2\C(=C/C(=C\3/C=C4C=CC=CC4=N3)/N2)OC)C.CS(=O)(=O)O
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	81 mg/mL (195.89 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.18 mL	120.92 mL	241.84 mL
0.5 mM	4.84 mL	24.18 mL	48.37 mL
1 mM	2.42 mL	12.09 mL	24.18 mL
5 mM	0.48 mL	2.42 mL	4.84 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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