Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
Targets
Target
Value
Cell Research
Cell Line
Type
Value
Description
References
Animal Research
Olaparib was used by diluting 50 mg ml−1 stocks in DMSO with 10% 2-hydroxyl-propyl-β-cyclodextrine/PBS such that the final volume administered by intraperitoneal (i.p.) injection was 10 µl g−1 of body weight. When the tumors reached a size of ≈150 mm3, 5 mg kg−1 olaparib was given i.p. daily. [1]
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
溶解性数据
In vitro (25°C)
DMSO
Warmed: 74 mg/mL (170.32 mM)
Water
<1 mg/mL
Ethanol
Insoluble
In vivo
4% DMSO+30% PEG 300+ddH2O
4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
