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ON-01910 (rigosertib)

ON-01910 (rigosertib)

Name: ON-01910 (rigosertib)
SKU: A10673

目录号: A10673

PLK 抑制剂

ON-01910 (rigosertib) Chemical Structure

CAS NO. 1225497-78-8

ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。

库存：现货

规格	价格	数量
5 mg	￥ 420.00
10 mg	￥ 700.00
50 mg	￥ 1,960.00
100 mg	￥ 3,360.00
10mM * 1mL in DMSO	￥ 812.00

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生物活性

ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。

靶点信息

PLK1 (Cell-free assay)
9 nM

溶解度 *

In vitro (25°C)	DMSO	85 mg/mL (179.52 mM)
	Water	85 mg/mL (179.52 mM)
	Ethanol	Insoluble
In vivo	water	90 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.12 mL	105.6 mL	211.19 mL
0.5 mM	4.22 mL	21.12 mL	42.24 mL
1 mM	2.11 mL	10.56 mL	21.12 mL
5 mM	0.42 mL	2.11 mL	4.22 mL

*The above data is based on the productmolecular weight 473.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10673
作用机制	Inhibitor (抑制剂)
M. Wt	473.5
Formula	C21H24NNaO8S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1225497-78-8
Synonyms	ON01910, ON 01910.Na, Estybon, Novonex, Rigosertib
SMILES	COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]