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ON 146040是第一个靶向STAT3和STAT5途径的PI3K和BCR-ABL双重抑制剂；抑制PI3Kα/δ同工型，IC50为14/20 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.43 mL | 102.13 mL | 204.27 mL |
| 0.5 mM | 4.09 mL | 20.43 mL | 40.85 mL |
| 1 mM | 2.04 mL | 10.21 mL | 20.43 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
*The above data is based on the productmolecular weight 489.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16266 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 489.55 |
| Formula | C24H23N7O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1404231-34-0 |
| Synonyms | ON-146040, ON146040 |
| SMILES | O=C(NC(C=NC(NC1=CC=C(N2CCN(C)CC2)C=C1)=N3)=C3S/4)C4=C\C5=CC=C([N+]([O-])=O)C=C5 |
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