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ONO 4817是广谱MMP抑制剂; MMP-12，MMP-2，MMP-8，MMP-13，MMP-9，MMP-3和MMP-7的Ki值分别为0.45、0.73、1.1、1.1、2.1、42和2500 nM，IC50 = 1600 MMP-1为nM）。 最高浓度为100μM的其他蛋白酶均无活性。 对鼠肾细胞癌的肺转移具有抗血管生成和抗侵袭特性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.01 mL | 120.06 mL | 240.11 mL |
| 0.5 mM | 4.8 mL | 24.01 mL | 48.02 mL |
| 1 mM | 2.4 mL | 12.01 mL | 24.01 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
*The above data is based on the productmolecular weight 416.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15305 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 416.47 |
| Formula | C22H28N2O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 223472-31-9 |
| Synonyms | MMP Inhibitor V |
| SMILES | CCOCOCC(CC(C)C(=O)NO)NC(=O)C1=CC=C(C=C1)OC2=CC=CC=C2 |
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