ONX 0912 (Oprozomib)

Name: ONX 0912 (Oprozomib)
SKU: A14181

目录号: A14181

Proteasome 抑制剂

ONX 0912 (Oprozomib) Chemical Structure

CAS NO. 935888-69-0

ONX 0912 (Oprozomib)是一种三肽环氧酮，可抑制对常规和硼替佐米治疗耐药的MM细胞的生长并诱导其凋亡。

库存：现货

规格	价格	数量
5 mg	￥ 735.00
10 mg	￥ 1,120.00
25 mg	￥ 2,100.00
10mM * 1mL in DMSO	￥ 980.00

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生物活性

ONX 0912 (Oprozomib)是一种三肽环氧酮，可抑制对常规和硼替佐米治疗耐药的MM细胞的生长并诱导其凋亡。

靶点信息

20S proteasome β5	20S proteasome LMP7
36 nM	82 nM

溶解度 *

In vitro	DMSO	86 mg/mL (161.47 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.79 mL	93.95 mL	187.9 mL
0.5 mM	3.76 mL	18.79 mL	37.58 mL
1 mM	1.88 mL	9.39 mL	18.79 mL
5 mM	0.38 mL	1.88 mL	3.76 mL

*The above data is based on the productmolecular weight 532.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14181
作用机制	Inhibitor (抑制剂)
M. Wt	532.2
Formula	C25H32N4O7S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	935888-69-0
Synonyms	Oprozomib,ONX-0912,ONX0912
SMILES	CC1=NC=C(S1)C(=O)N[C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C