ONX 0912 (Oprozomib)
目录号: A14181
Proteasome 抑制剂
ONX 0912 是一种三肽环氧酮,它能抑制对传统和硼替佐米疗法耐药的多发性骨髓瘤(MM)细胞的生长,并诱导凋亡。
Discription | ONX 0912 is a tripeptide epoxyketone, which inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies. | |||||
---|---|---|---|---|---|---|
Targets |
|
|||||
Cell Research |
|
目录号 | A14181 |
---|---|
分子式 | C25H32N4O7S |
分子量 | 532.2 |
CAS号 | 935888-69-0 |
SMILES | CC1=NC=C(S1)C(=O)N[C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C |
其他名称 | Oprozomib,ONX-0912,ONX0912 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 86 mg/mL (161.47 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.79 mL | 93.95 mL | 187.9 mL |
0.5 mM | 3.76 mL | 18.79 mL | 37.58 mL |
1 mM | 1.88 mL | 9.39 mL | 18.79 mL |
5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2