OSI-420

Name: OSI-420
SKU: A10678
Price: 315 CNY
Rating: 5 (2 reviews)

目录号: A10678

EGFR 抑制剂

2 篇发表文献

OSI-420（去甲基厄洛替尼，CP-473420）是一种口服活性的EGFR酪氨酸激酶抑制剂，通过抑制细胞内域来抑制受体酪氨酸激酶（TKs）。

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Grouped product items
规格	价格	库存
1mg	¥315.00	现货
2mg	¥490.00	现货
5mg	¥735.00	现货
10mg	¥1,330.00	现货
25mg	¥2,415.00	现货
50mg	¥3,605.00	现货
100mg	¥5,250.00	现货
*10mM 1mL in DMSO**	¥805.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用OSI-420 发表的2篇文献

Yuta Yamamoto, .et al. , J Pharm Anal, 2018, Apr; 8(2): 119-123 PMID: 29736298

Janet L. Martin, .et al. , Breast Cancer Res, 2017, 19: 90 PMID: 28778177

生物活性

Discription

OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by inhibition of the intercellular domain .

Targets

Target	Value

产品信息

目录号	A10678
分子式	C21H21N3O4.HCl
分子量	415.9
CAS号	183320-51-6
SMILES	COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl
其他名称	Desmethyl Erlotinib,CP-473420
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	Warmed: 75 mg/mL (180.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.04 mL	120.22 mL	240.44 mL
0.5 mM	4.81 mL	24.04 mL	48.09 mL
1 mM	2.4 mL	12.02 mL	24.04 mL
5 mM	0.48 mL	2.4 mL	4.81 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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