OSI-930
目录号: A10679
c-Kit/VEGFR 抑制剂
OSI-930 是一种强效的抑制剂,针对 Kit、KDR、Flt、CSF-1R、c-Raf 和 Lck,其半抑制浓度(IC50)分别为 80 nM、9 nM、8 nM、15 nM、41 nM 和 22 nM。
Discription | OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. | ||
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Targets |
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目录号 | A10679 |
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分子式 | C22H16F3N3O2S |
分子量 | 443.4 |
CAS号 | 728033-96-3 |
SMILES | C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 85 mg/mL (191.68 mM) | |
Water | Insoluble | ||
Ethanol | 3 mg/mL | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 22.55 mL | 112.76 mL | 225.53 mL |
0.5 mM | 4.51 mL | 22.55 mL | 45.11 mL |
1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2