产品详情

生物活性

OTX015是口服可生物利用的BRD2，BRD3和BRD4的小分子抑制剂（EC50s = 10-19 nM）。

靶点信息

BRDs (Cell-free assay)
10-19 nM(EC50)

溶解度 *

In vitro (25°C)	DMSO	89 mg/mL (180.9 mM)
	Water	Insoluble
	Ethanol	89 mg/mL
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.33 mL	101.63 mL	203.26 mL
0.5 mM	4.07 mL	20.33 mL	40.65 mL
1 mM	2.03 mL	10.16 mL	20.33 mL
5 mM	0.41 mL	2.03 mL	4.07 mL

*The above data is based on the productmolecular weight 491.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13890
作用机制	Inhibitor (抑制剂)
M. Wt	491.99
Formula	C25H22ClN5O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	202590-98-5
Synonyms	OTX 015, OTX-015
SMILES	CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C