P-gp

Inhibitory Selectivity

Catalog No.	Inhibitor Name	P-gp	Other
A10549	Zosuquidar 3HCl	**
A11584	Tariquidar	***
A12324	Elacridar (GF120918)		BCRP

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Quick View
P-gp inhibitor 1

Catalog No. A13384
Quick View

添加到收藏
P-gp inhibitor

P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. 了解更多

Bulk Inquiry
Quick View
Norverapamil hydrochloride

Catalog No. A12249
Quick View

添加到收藏
P-gp inhibitor

Norverapamil hydrochloride ((??)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. 了解更多

Bulk Inquiry
Quick View
TTT-28

Catalog No. A13033
Quick View

添加到收藏
ABCB1 (P-gp/MDR1) inhibitor

TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity. 了解更多

Bulk Inquiry
Quick View
Zosuquidar

Catalog No. A15289
Quick View

添加到收藏
P-gp 抑制剂

Zosuquidar是P-糖蛋白介导的多药耐药性的有效调节剂，Ki为60 nM。了解更多

Bulk Inquiry
Quick View
Elacridar hydrochloride

Catalog No. A15077
Quick View

添加到收藏
P-gp 抑制剂

Elacridar hydrochloride是一种P-糖蛋白抑制剂，已在体内和体外用作P-糖蛋白（Pgp）的工具抑制剂，以研究转运蛋白在处理各种测试分子中的作用。了解更多

Bulk Inquiry Free Sample
Quick View
FD 12-9

Catalog No. A18393
Quick View

添加到收藏
P-gp/BCRP dual 抑制剂

FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity. 了解更多

Bulk Inquiry
Quick View
KS-176

Catalog No. A16195
Quick View

添加到收藏
BCRP 抑制剂

KS-176是乳腺癌抗性蛋白（BCRP）多药转运蛋白的有效和选择性抑制剂（在Pheo A和Hoechst 33342分析中，IC50值分别为0.59和1.39 uM）。了解更多

Bulk Inquiry
Quick View
MC 70 HCl

Catalog No. A16080
Quick View

添加到收藏
P-gp 抑制剂

MC 70 HCl是有效的P-gp抑制剂（EC50 = 0.69 uM）。了解更多

Bulk Inquiry
Quick View
Laniquidar

Catalog No. A13532
Quick View

添加到收藏
P-gp 抑制剂

Laniquidar是第三代P-gp抑制剂，已在临床试验中用于调节多药耐药转运蛋白。了解更多

Bulk Inquiry
Quick View
ONT-093

Catalog No. A13531
Quick View

添加到收藏
P-gp 抑制剂

ONT-093是口服可生物利用的P-糖蛋白泵抑制剂，可潜在逆转接受癌症化学疗法的患者的多药耐药性。了解更多

Bulk Inquiry
Quick View
XR9576

Catalog No. A13961
Quick View

添加到收藏
P-glycoprotein 抑制剂

XR9576是一种 P-glycoprotein (P-gp) 抑制剂，Kd值为5.1 nM。正在研究中作为抗癌多药耐药性的佐剂。了解更多

Bulk Inquiry
Quick View
Tariquidar (XR9576)

Catalog No. A11584
Quick View

添加到收藏
P-gp 抑制剂

Tariquidar (XR9576)是一种P-糖蛋白药物外排泵抑制剂。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Yuko Sasaki, .et al. Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices, Biol Pharm Bull, 2022, 45(9):1246-1253 PMID: 36047192
- Sugisawa N, .et al. Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell, Mol Pharm, 2018, Sep 4;15(9):4021-4030 PMID: 30052463
- Samy A. F. Morad, .et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer, Biochem Pharmacol, 2017, Apr 15; 130: 21-33 PMID: 28189725
- Debora Petroni, .et al. Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein, Mol Imaging Biol, 2016, Dec;18(6):916-923 PMID: 27234445
Quick View
Elacridar (GF120918)

Catalog No. A12324
Quick View

添加到收藏
P-gp & BCRP 抑制剂

Elacridar (GF120918)是一种原型BCRP抑制剂，可抑制Bcrp1介导的转运。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Leo Shen, .et al. A forward genetic screen identifies modifiers of rocaglate responsiveness, Sci Rep, 2021, Sep 16;11(1):18516 PMID: 34531456
Quick View
PSC-833 (Valspodar)

Catalog No. A11080
Quick View

添加到收藏
MDR1/P-gp 抑制剂

PSC-833 (Valspodar)是一种P-糖蛋白（P-gp）调节剂，可抑制P-gp介导的多药耐药性（MDR）。了解更多

Product Citations (5)

Bulk Inquiry
- Somin Lee, .et al. BBB-on-a-Chip: Modeling Functional Human Blood-Brain Barrier by Mimicking 3D Brain Angiogenesis Using Microfluidic Chip, Methods Mol Biol, 2022, 2492:251-263 PMID: 35733049
- Somin Lee, .et al. 3D brain angiogenesis model to reconstitute functional human blood?Cbrain barrier in vitro, ?Biotechnol Bioeng, 2019, 10 November
- Somin Lee, .et al. 3D brain angiogenesis model to reconstitute maturation of functional human blood-brain barrier in vitro, bioRxiv, 2018, Nov. 18
- Watanabe N, .et al. The possible clinical impact of risperidone on P-glycoprotein-mediated transport of tacrolimus: A case report and in vitro study, Biopharm Drug Dispos, 2018, Jan;39(1):30-37 PMID: 29055041
- Higashi H, .et al. In Vitro P-Glycoprotein-Mediated Transport of Tadalafil: A Comparison with Sildenafil, Biol Pharm Bull, 2017, 40(8):1314-1319 PMID: 28769012