Pacritinib (SB1518)

Name: Pacritinib (SB1518)
SKU: A12694
Price: 175 CNY
Rating: 5 (2 reviews)

目录号: A12694

JAK2/FLT3 抑制剂

2 篇发表文献

Pacritinib，也被称为 SB1518，是一种口服生物可利用的 Janus kinase 2 (JAK2) 和 JAK2 突变体 JAK2V617F 的抑制剂，具有潜在的抗肿瘤活性。Pacritinib 与 JAK2 竞争 ATP 结合，这可能导致抑制 JAK2 激活，抑制 JAK-STAT 信号通路，从而引发依赖半胱天冬酶的凋亡。

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥350.00	现货
10mg	¥560.00	现货
25mg	¥1,015.00	现货
50mg	¥1,610.00	现货
100mg	¥2,730.00	现货
500mg	¥6,440.00	现货
*10mM 1mL in DMSO**	¥1,736.00	现货
更大包装	更多折扣

大包装询价

Notify me when the price drops

全国免运费, 顺丰次日达

重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Pacritinib (SB1518)发表的2篇文献

Angelina T Regua, .et al. , Cancer Lett, 2024, Jun 7:597:217023 PMID: 38852701

Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154

生物活性

Discription

Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12694
分子式	C28H32N4O3
分子量	472.58
CAS号	937272-79-2
SMILES	C1CCN(C1)CCOC2=C3COC/C=C/COCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2
其他名称	SB-1518; SB 1518
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	Warmed: 10 mg/mL (21.15 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.16 mL	105.8 mL	211.6 mL
0.5 mM	4.23 mL	21.16 mL	42.32 mL
1 mM	2.12 mL	10.58 mL	21.16 mL
5 mM	0.42 mL	2.12 mL	4.23 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords: 购买 Pacritinib (SB1518) | Pacritinib (SB1518) 供应商 | Pacritinib (SB1518) 花费 | Pacritinib (SB1518) 生产商 | 订购 Pacritinib (SB1518) | Pacritinib (SB1518) 代理商 | 购买 937272-79-2 | 937272-79-2 供应商 | 937272-79-2 花费 | 937272-79-2 生产商 | 订购 937272-79-2 | 937272-79-2 代理商