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PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (??24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.93 mL | 89.67 mL | 179.35 mL |
| 0.5 mM | 3.59 mL | 17.93 mL | 35.87 mL |
| 1 mM | 1.79 mL | 8.97 mL | 17.93 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.59 mL |
*The above data is based on the productmolecular weight 557.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18616 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 557.58 |
| Formula | C24H27N7O7S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2084811-68-5 |
| SMILES | O=C(O)C1=CC=CC(S(=O)(NCCN2N=NC(CCNC(CCC(NC3=CC=CC(C(N)=O)=C3)=O)=O)=C2)=O)=C1 |
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