Pazopanib HCl (GW786034)

Name: Pazopanib HCl (GW786034)
SKU: A10699
Price: 175 CNY
Rating: 5 (4 reviews)

目录号: A10699

VEGFR/PDGFR/FGFR 抑制剂

4 篇发表文献

Pazopanib 是一种强效且选择性的多靶点受体酪氨酸激酶抑制剂，能够抑制 VEGFR-1、VEGFR-2、VEGFR-3、PDGFR-α/β 和 c-kit，从而阻断肿瘤生长并抑制血管生成。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥245.00	现货
25mg	¥385.00	现货
50mg	¥630.00	现货
100mg	¥945.00	现货
200mg	¥1,645.00	现货
500mg	¥2,590.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Pazopanib HCl (GW786034)发表的4篇文献

Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

Majid Momeny, .et al. , Life Sci, 2021, Dec 15;287:120100 PMID: 34715143

Hideharu Yamada, .et al. , Oncol Lett, 2021, Jun;21(6):455 PMID: 33907565

Majid Momeny, .et al. , Eur J Pharmacol, 2020, 882:173298

生物活性

Discription

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Targets

Target	Value

产品信息

目录号	A10699
分子式	C21H23N7O2S.HCl
分子量	474
CAS号	635702-64-6
SMILES	CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	15 mg/mL (31.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.1 mL	105.49 mL	210.97 mL
0.5 mM	4.22 mL	21.1 mL	42.19 mL
1 mM	2.11 mL	10.55 mL	21.1 mL
5 mM	0.42 mL	2.11 mL	4.22 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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