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PD173955

目录号: A13120
Bcr-Abl 抑制剂
PD-173955 是一种 src酪氨酸激酶抑制剂。PD173955 抑制了依赖 Bcr-Abl 的细胞生长。PD173955 在 G(1) 阶段引起细胞周期阻滞。PD173955 在 Bcr-Abl 的激酶抑制测定中具有 IC(50) 值为 1-2 nM,并且在细胞生长测定中,它抑制了依赖 Bcr-Abl 的底物酪氨酸磷酸化。PD173955 抑制了依赖 kit 配体的 c-kit 自磷酸化(IC(50) = 约 25 nM)和依赖 kit 配体的 M07e 细胞增殖(IC(50) = 40 nM),但对依赖白细胞介素 3(IC(50) = 250 nM)或粒细胞巨噬细胞集落刺激因子(IC(50) = 1 微米)的细胞生长影响较小。
Grouped product items
规格 价格 库存 数量
1mg
¥245.00
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5mg
¥525.00
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10mg
¥980.00
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25mg
¥2,030.00
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50mg
¥3,150.00
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100mg
¥4,760.00
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10mM * 1mL in DMSO
¥1,120.00
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生物活性
Discription PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.
Targets
Target Value
Cell Research
Cell Line Type Value Description References
产品信息
目录号 A13120
分子式 C21H16Cl2N4OS
分子量 443.35
CAS号 260415-63-2
SMILES CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC
其他名称 PD 173955; PD-173955
储存条件

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据
In vitro DMSO Warmed: 13 mg/mL (29.32 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.56 mL 112.78 mL 225.56 mL
0.5 mM 4.51 mL 22.56 mL 45.11 mL
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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