PD173955

Name: PD173955
SKU: A13120

目录号: A13120

Bcr-Abl 抑制剂

PD173955 Chemical Structure

CAS NO. 260415-63-2

PD-173955是src酪氨酸激酶抑制剂。PD173955抑制Bcr-Abl依赖的细胞生长。PD173955显示G（1）中的细胞周期停滞。PD173955在Bcr-Abl的激酶抑制测定中的IC（50）为1-2 nM，在细胞生长测定中，其抑制Bcr-Abl依赖性底物酪氨酸磷酸化。 PD173955抑制试剂盒配体依赖性c-kit自磷酸化（IC（50）=约25 nM）和试剂盒配体依赖性M07e细胞增殖（IC（50）= 40 nM），但对白介素3依赖性（IC （50）= 250 nM）或粒细胞巨噬细胞集落刺激因子（IC（50）= 1 microM）依赖性细胞生长。

库存：现货

规格	价格	数量
5 mg	￥ 840.00
10 mg	￥ 1,400.00
25 mg	￥ 2,450.00
50 mg	￥ 4,200.00

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产品详情

生物活性

靶点信息

Bcr-Abl	Src
1 nM-2 nM	22 nM

溶解度 *

In vitro	DMSO	Warmed: 13 mg/mL (29.32 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.56 mL	112.78 mL	225.56 mL
0.5 mM	4.51 mL	22.56 mL	45.11 mL
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13120
作用机制	Inhibitor (抑制剂)
M. Wt	443.35
Formula	C21H16Cl2N4OS
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	260415-63-2
Synonyms	PD 173955; PD-173955
SMILES	CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC