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YAP-TEAD-IN-1 (Peptide 17)

目录号: A15858
Peptide 17 是一种抑制 YAP-TEAD 蛋白-蛋白相互作用的抑制剂,其在治疗涉及 YAP 的癌症中具有潜在应用,IC50 为 25nM。
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  • Alexander Howard, .et al. , Exp Dermatol, 2022, Oct;31(10):1477-1499 PMID: 35913427
  • 生物活性
    Discription Peptide 17 is a inhibitor of this YAP-TEAD protein-protein interaction which has potential usage in treatment of YAP-involved cancers with IC50 of 25nM.
    产品信息
    目录号 A15858
    分子式 C93H144ClN23O21S2
    分子量 2019.86
    CAS号 1659305-78-8
    SMILES C1(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2[C@H]1CCC2)CCCC)CCCCN)CCCNC(=N)N)CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)C)C(C)C)Cc1cc(ccc1)Cl)C(=O)N[C@H](C(=O)N1[C@H](C(=O)N2[C@H](C(=O)N[C@H](C(=O)N)CCC(=O)O)CCC2)CCC1)CCCCN)Cc1ccccc1)CO)C
    其他名称 YAP-TEAD Inhibitor 1 , Peptide-17, Peptide17
    储存条件

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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