Nirogacestat (PF-03084014)

Name: Nirogacestat (PF-03084014)
SKU: A11259
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A11259

γ-secretase 抑制剂

PF-03084014 是一种可逆的、选择性的 γ-secretase 抑制剂，其 IC50 值为 6.2 nM。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
5mg	¥490.00	现货
10mg	¥875.00	现货
25mg	¥1,890.00	现货
50mg	¥3,500.00	现货
100mg	¥6,650.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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Data Sheet

SDS

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生物活性

Discription

PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM .

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11259
分子式	C27H41F2N5O
分子量	489.64
CAS号	1290543-63-3, 865773-15-5 (mesylate)
SMILES	CCC[C@@H](C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)N[C@H]2CCC3=CC(=CC(=C3C2)F)F
其他名称	PF 03084014, PF03084014
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	Warmed: 89 mg/mL (181.76 mM)
	Water	Insoluble
	Ethanol	Warmed: 89 mg/mL (181.76 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.42 mL	102.12 mL	204.23 mL
0.5 mM	4.08 mL	20.42 mL	40.85 mL
1 mM	2.04 mL	10.21 mL	20.42 mL
5 mM	0.41 mL	2.04 mL	4.08 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂