PF-03814735

Name: PF-03814735
SKU: A11171

目录号: A11171

Aurora A/B Kinase 抑制剂

PF-03814735 Chemical Structure

CAS NO. 942487-16-3

PF-03814735是一种新颖，有效且可逆的Aurora A/B抑制剂，IC50为0.8 nM/5 nM，对Flt3，FAK，TrkA的效力较低，对Met和FGFR1的活性最低。

库存：缺货

规格	价格
5 mg	￥ 630.00
10 mg	￥ 1,120.00
50 mg	￥ 4,200.00
100 mg	￥ 8,400.00

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产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

PF-03814735是一种新颖，有效且可逆的Aurora A/B抑制剂，IC50为0.8 nM/5 nM，对Flt3，FAK，TrkA的效力较低，对Met和FGFR1的活性最低。

靶点信息

Aurora A	Aurora B	FLT1	FAK	TrkA
0.8 nM	5 nM	10 nM	22 nM	30 nM

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.08 mL	105.38 mL	210.76 mL
0.5 mM	4.22 mL	21.08 mL	42.15 mL
1 mM	2.11 mL	10.54 mL	21.08 mL
5 mM	0.42 mL	2.11 mL	4.22 mL

*The above data is based on the productmolecular weight 474.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11171
作用机制	Inhibitor (抑制剂)
M. Wt	474.48
Formula	C23H25F3N6O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	942487-16-3
Synonyms	PF03814735
SMILES	CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F