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PF-04880594是RAF抑制剂，BRAF/BRAFV599E和c-RAF的IC50值分别为0.19 nM/0.13 nM和0.39 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.36 mL | 126.78 mL | 253.56 mL |
| 0.5 mM | 5.07 mL | 25.36 mL | 50.71 mL |
| 1 mM | 2.54 mL | 12.68 mL | 25.36 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12739 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 394.38 |
| Formula | C19H16F2N8 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1111636-35-1 |
| Synonyms | PF-04880594, PF04880594, PF 04880594 |
| SMILES | C1=CNC2=NC=C(C=C21)C3=NN(C=C3C4=NC(=NC=C4)NCCC#N)CC(F)F |
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