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PF-04929113 (SNX-5422)

PF-04929113 (SNX-5422)

Name: PF-04929113 (SNX-5422)
SKU: A11074

目录号: A11074

Hsp90 抑制剂

Product Citations (2)

PF-04929113 (SNX-5422) Chemical Structure

CAS NO. 908115-27-5

PF-04929113 (SNX-5422)是一种有效的，选择性的HSP90抑制剂，Kd为41 nM，且诱导Her-2降解，IC50为37 nM。

库存：现货

规格	价格	数量
5 mg	￥ 1,050.00
10 mg	￥ 1,960.00
50 mg	￥ 4,200.00
100 mg	￥ 7,350.00
10mM * 1mL in DMSO	￥ 1,505.00

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生物活性

PF-04929113 (SNX-5422)是一种有效的，选择性的HSP90抑制剂，Kd为41 nM，且诱导Her-2降解，IC50为37 nM。

靶点信息

HER2	HSP90
37 nM	41 nM(Kd)

溶解度 *

In vitro (25°C)	DMSO	90 mg/mL (172.57 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (7.66 mM)
In vivo	0.5% CMC+0.25% Tween 80	23 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.18 mL	95.88 mL	191.75 mL
0.5 mM	3.84 mL	19.18 mL	38.35 mL
1 mM	1.92 mL	9.59 mL	19.18 mL
5 mM	0.38 mL	1.92 mL	3.84 mL

*The above data is based on the productmolecular weight 521.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11074
作用机制	Inhibitor (抑制剂)
M. Wt	521.5
Formula	C25H30F3N5O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	908115-27-5
Synonyms	PF04929113, SNX5422
SMILES	CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C