PF-04995274

Name: PF-04995274
SKU: A22497
Price: 140 CNY
Rating: 5 (288 reviews)

目录号: A22497

5-HT4 receptor partial agonist

PF-04995274 是一种 5-羟色胺 (5-HT) 受体亚型 5-HT4A、5-HT4B、5-HT4D 和 5-HT4E 的部分激动剂（在放射配体结合实验中的 Kis 分别为 0.36、0.46、0.15 和 0.32 nM）。它能增加表达 5-HT4A、5-HT4B、5-HT4D 和 5-HT4E 受体的 HEK293 细胞中的 cAMP 水平（对于人类重组受体，EC50s 分别为 0.47、0.36、0.37 和 0.26 nM）。当以 0.032 mg/kg 的剂量给药时，PF-04995274 能减少东莨菪碱引起的在 Morris 水迷宫中的行走距离增加。

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Grouped product items
规格	价格	库存
1mg	¥140.00	现货
5mg	¥420.00	现货
10mg	¥735.00	现货
25mg	¥1,400.00	现货
50mg	¥2,520.00	现货
100mg	¥3,675.00	现货
*10mM 1mL in DMSO**	¥420.00	现货
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Data Sheet

SDS

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生物活性

Discription

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay).1 It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A22497
分子式	C23H32N2O6
分子量	432.52
CAS号	1331782-27-4
SMILES	OC1(CN2CCC(COC3=NOC4=C3C(O[C@H]5COCC5)=CC=C4)CC2)CCOCC1
其他名称	PF-04995274, PF 04995274, PF04995274, PF-4995274, PF 4995274, PF4995274.
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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