PF-05089771

Name: PF-05089771
SKU: A16365
Price: 385 CNY
Rating: 5 (288 reviews)

目录号: A16365

Nav1.7 Inhibitor

PF-05089771 是一种选择性 Nav1.7 抑制剂（IC50 = 11 nM），它与 domain IV 的电压传感器域（VSD）发生相互作用。

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规格	价格	库存
1mg	¥385.00	现货
5mg	¥980.00	现货
10mg	¥1,330.00	现货
25mg	¥2,240.00	现货
50mg	¥3,605.00	现货
100mg	¥7,035.00	现货
*10mM 1mL in DMSO**	¥1,120.00	现货
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Data Sheet

SDS

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生物活性

Discription

PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV.

Cell Research

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Cell Line	Type	Value	Description	References
HEK293	IC50	> 10 μM	Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC50	> 10 μM	Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells measured after 5 to 10 mins post compound washout by PatchXpress automated electrophysiology method	[PMID: 28465103]
HEK293	IC50	0.011 μM	Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC50	0.11 μM	Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC50	0.16 μM	Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC50	0.85 μM	Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC50	10 μM	Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC50	11 nM	Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells measured after 5 to 10 mins post compound washout by PatchXpress automated electrophysiology method	[PMID: 28465103]
HEK293	IC50	11 μM	Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]
HEK293	IC50	25 μM	Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assay	[PMID: 31012583]

Showing 1 to 10 of 15 entries

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产品信息

目录号	A16365
分子式	C18H12Cl2FN5O3S2
分子量	500.34
CAS号	1235403-62-9
SMILES	O=S(C1=CC(Cl)=C(OC2=CC=C(Cl)C=C2C3=C(N)NN=C3)C=C1F)(NC4=CSC=N4)=O
其他名称	PF 05089771, PF05089771
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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