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PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.65 mL | 88.24 mL | 176.48 mL |
| 0.5 mM | 3.53 mL | 17.65 mL | 35.3 mL |
| 1 mM | 1.76 mL | 8.82 mL | 17.65 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.53 mL |
*The above data is based on the productmolecular weight 566.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12572 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 566.63 |
| Formula | C31H31FN8O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1421502-62-6 |
| Synonyms | PF06263276, PF 06263276 |
| SMILES | FC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CN(C(C6=NC=C(N7CCCCC7)N=C6)=O)CC5)N4)=C3C=C2)=C1 |
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