Lorlatinib (PF-06463922)

Name: Lorlatinib (PF-06463922)
SKU: A14207
Price: 140 CNY
Rating: 5 (288 reviews)

目录号: A14207

ALK 抑制剂

Lorlatinib (PF-06463922) 是一种强效的双重 ALK/ROS1 抑制剂，其 Ki 值分别为 ROS1 <0.02 nM、ALK (WT) <0.07 nM 和 ALK (L1196M) 0.7 nM。

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Grouped product items
规格	价格	库存
1mg	¥140.00	现货
5mg	¥385.00	现货
10mg	¥595.00	现货
25mg	¥1,015.00	现货
50mg	¥1,855.00	现货
100mg	¥3,640.00	现货
500mg	¥15,575.00	现货
*10mM 1mL in DMSO**	¥462.00	现货
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Data Sheet

SDS

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生物活性

Discription

Lorlatinib (PF-06463922) is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A14207
分子式	C21H19FN6O2
分子量	406.41
CAS号	1454846-35-5
SMILES	C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
其他名称	PF 06463922, PF06463922
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 70 mg/mL (172.23 mM)
	Water	Insoluble
	Ethanol	Warmed: 26 mg/mL
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.61 mL	123.03 mL	246.06 mL
0.5 mM	4.92 mL	24.61 mL	49.21 mL
1 mM	2.46 mL	12.3 mL	24.61 mL
5 mM	0.49 mL	2.46 mL	4.92 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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