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PF-06651600是一种有效且不可逆的JAK3选择性抑制剂，IC50为33.1 nM，但对JAK1，JAK2和TYK2没有活性（IC50> 10 000 nM）。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.05 mL | 175.23 mL | 350.46 mL |
| 0.5 mM | 7.01 mL | 35.05 mL | 70.09 mL |
| 1 mM | 3.5 mL | 17.52 mL | 35.05 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7.01 mL |
*The above data is based on the productmolecular weight 285.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16803 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 285.34 |
| Formula | C15H19N5O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1792180-81-4 |
| Synonyms | PF06651600, PF 06651600 |
| SMILES | C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O |
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