PF-2341066 (Crizotinib)

Name: PF-2341066 (Crizotinib)
SKU: A10712

目录号: A10712

ALK/ c-Met 抑制剂

Product Citations (6)

PF-2341066 (Crizotinib) Chemical Structure

CAS NO. 877399-52-5

PF-2341066 (Crizotinib)是c-Met激酶和NPM-ALK的抑制剂。PF-2341066抑制ALK阳性ALCL细胞中的细胞增殖（IC50 = 30 nM）。

库存：现货

规格	价格	数量
5 mg	￥ 210.00
10 mg	￥ 350.00
50 mg	￥ 455.00
100 mg	￥ 630.00

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产品详情

生物活性

PF-2341066 (Crizotinib)是c-Met激酶和NPM-ALK的抑制剂。PF-2341066抑制ALK阳性ALCL细胞中的细胞增殖（IC50 = 30 nM）。

靶点信息

c-Met (A549, MDA-MB-231, GTL-16, HT29, 786-O, Colo-205, A498 cells)	ALK (Karpas299 cells)
11 nM	24 nM

溶解度 *

In vitro (25°C)	DMSO	8 mg/mL (17.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+dd H2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.21 mL	111.04 mL	222.07 mL
0.5 mM	4.44 mL	22.21 mL	44.41 mL
1 mM	2.22 mL	11.1 mL	22.21 mL
5 mM	0.44 mL	2.22 mL	4.44 mL

*The above data is based on the productmolecular weight 450.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10712
作用机制	Inhibitor (抑制剂)
M. Wt	450.3
Formula	C21H22Cl2FN5O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	877399-52-5
Synonyms	PF02341066
SMILES	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N