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PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.59 mL | 87.94 mL | 175.87 mL |
| 0.5 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 1 mM | 1.76 mL | 8.79 mL | 17.59 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
*The above data is based on the productmolecular weight 568.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15127 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 568.59 |
| Formula | C29H31F3N6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1341224-83-6 |
| Synonyms | INCB8761 |
| SMILES | O[C@]1(CC[C@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5 |
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