PF-4136309

Name: PF-4136309
SKU: A15127

目录号: A15127

CCR2 antagonist

PF-4136309 Chemical Structure

CAS NO. 1341224-83-6

PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

库存：现货

规格	价格	数量
5 mg	￥ 504.00
10 mg	￥ 868.00
50 mg	￥ 2,576.00
100 mg	￥ 5,152.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.59 mL	87.94 mL	175.87 mL
0.5 mM	3.52 mL	17.59 mL	35.17 mL
1 mM	1.76 mL	8.79 mL	17.59 mL
5 mM	0.35 mL	1.76 mL	3.52 mL

*The above data is based on the productmolecular weight 568.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15127
作用机制	Antagonist (拮抗剂)
M. Wt	568.59
Formula	C29H31F3N6O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1341224-83-6
Synonyms	INCB8761
SMILES	O[C@]1(CC[C@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5