PF 431396

Name: PF 431396
SKU: A11142

目录号: A11142

FAK/PYK2 抑制剂

PF 431396 Chemical Structure

CAS NO. 717906-29-1

PF 431396是一种双粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶2（PYK2）抑制剂（IC50值分别为2和11 nM）。

库存：现货

规格	价格	数量
10 mg	￥ 560.00
25 mg	￥ 1,120.00
50 mg	￥ 1,960.00
100 mg	￥ 3,360.00
10mM * 1mL in DMSO	￥ 735.00

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生物活性

PF 431396是一种双粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶2（PYK2）抑制剂（IC50值分别为2和11 nM）。

靶点信息

FAK	PYK2
2 nM	11 nM

溶解度 *

In vitro	DMSO	94 mg/mL (185.58 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.74 mL	98.72 mL	197.43 mL
0.5 mM	3.95 mL	19.74 mL	39.49 mL
1 mM	1.97 mL	9.87 mL	19.74 mL
5 mM	0.39 mL	1.97 mL	3.95 mL

*The above data is based on the productmolecular weight 506.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11142
作用机制	Inhibitor (抑制剂)
M. Wt	506.5
Formula	C22H21F3N6O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	717906-29-1
Synonyms	PF-431396
SMILES	CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C