PF-5274857

Name: PF-5274857
SKU: A12775

目录号: A12775

Smoothened 抑制剂

PF-5274857 Chemical Structure

CAS NO. 1373615-35-0

PF-5274857是一种新型Smo拮抗剂，它以4.6±1.1 nmol/L的K（i）特异性结合Smo，并以2.7±1.4 nmol/L的IC（50）完全阻断下游基因Gli1的转录活性。在细胞中。

库存：现货

规格	价格	数量
5 mg	￥ 567.00
10 mg	￥ 966.00
25 mg	￥ 1,701.00
50 mg	￥ 2,835.00
10mM * 1mL in DMSO	￥ 1,757.00

大包装询价

或

添加到收藏

产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

PF-5274857是一种新型Smo拮抗剂，它以4.6±1.1 nmol/L的K（i）特异性结合Smo，并以2.7±1.4 nmol/L的IC（50）完全阻断下游基因Gli1的转录活性。在细胞中。

靶点信息

Smoothened	Smoothened
4.6 nM(Ki)	5.8 nM

溶解度 *

In vitro (25°C)	DMSO	83 mg/mL (189.95 mM)
	Water	83 mg/mL (189.95 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.89 mL	114.43 mL	228.85 mL
0.5 mM	4.58 mL	22.89 mL	45.77 mL
1 mM	2.29 mL	11.44 mL	22.89 mL
5 mM	0.46 mL	2.29 mL	4.58 mL

*The above data is based on the productmolecular weight 436.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12775
作用机制	Inhibitor (抑制剂)
M. Wt	436.96
Formula	C20H25ClN4O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1373615-35-0
Synonyms	PF5274857, PF 5274857
SMILES	CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C