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PF-543是一种新型选择性SK-1抑制剂，可与鞘氨醇竞争性抑制SK-1活性。
靶点信息
| SphK1 | SphK1 | |||
| 2.0 nM | 3.6 nM(Ki) |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.48 mL | 107.39 mL | 214.78 mL |
| 0.5 mM | 4.3 mL | 21.48 mL | 42.96 mL |
| 1 mM | 2.15 mL | 10.74 mL | 21.48 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13039 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 465.6 |
| Formula | C27H31NO4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1415562-82-1 |
| Synonyms | PF543,PF 543 |
| SMILES | CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCC[C@@H]3CO)CS(=O)(=O)C4=CC=CC=C4 |
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