PF 670462
目录号: A11781
Casein kinase 抑制剂
强效且选择性的酪蛋白激酶1ε（CK1ε）和CK1δ抑制剂（IC50值分别为7.7和14纳摩尔），对其他42种常见激酶显示出超过30倍的选择性。抑制PER蛋白核内转运（EC50 = 290纳摩尔），导致昼夜节律的相位变化，并减弱体内甲基苯丙胺刺激的运动活性。
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生物活性
| Discription | Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo. | ||
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产品信息
| 目录号 | A11781 |
|---|---|
| 分子式 | C19H20FN5.2HCl |
| 分子量 | 410.3 |
| CAS号 | 950912-80-8 |
| SMILES | C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl |
| 其他名称 | PF670462 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 80 mg/mL (194.97 mM) | |
| Water | 80 mg/mL (194.97 mM) | ||
| Ethanol | 27 mg/mL (65.79 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.37 mL | 121.86 mL | 243.72 mL |
| 0.5 mM | 4.87 mL | 24.37 mL | 48.74 mL |
| 1 mM | 2.44 mL | 12.19 mL | 24.37 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 950912-80-8 | 950912-80-8 供应商 | 950912-80-8 花费 | 950912-80-8 生产商 | 订购 950912-80-8 | 950912-80-8 代理商