PF-8380
目录号: A11527
Autotaxin 抑制剂
PF-8380 是一种强效且特异性的自噬酶抑制剂，其 IC50 值为 2.8 nM。
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生物活性
| Discription | PF-8380 is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM. | |||||
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| Targets |
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| Cell Research |
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产品信息
| 目录号 | A11527 |
|---|---|
| 分子式 | C22H21Cl2N3O5 |
| 分子量 | 478.33 |
| CAS号 | 1144035-53-9 |
| SMILES | C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl |
| 其他名称 | PF 8380, PF8380 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 89 mg/mL (186.06 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1%cmc-na | 14 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.91 mL | 104.53 mL | 209.06 mL |
| 0.5 mM | 4.18 mL | 20.91 mL | 41.81 mL |
| 1 mM | 2.09 mL | 10.45 mL | 20.91 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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