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PHA 408是一种有效的，高度选择性的，具有ATP竞争性的IKB激酶2（IKK-2）抑制剂（IC50：40 nM），它以相对较慢的释放速率紧密结合IKK-2。 强烈推荐您研究IKK-2调节NF-KB信号传导机制的工具。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.86 mL | 89.28 mL | 178.57 mL |
| 0.5 mM | 3.57 mL | 17.86 mL | 35.71 mL |
| 1 mM | 1.79 mL | 8.93 mL | 17.86 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.57 mL |
*The above data is based on the productmolecular weight 560.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13108 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 560.02 |
| Formula | C29H27ClFN7O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 503555-55-3 |
| Synonyms | PHA-408, PHA408 |
| SMILES | CN1CCN(CC1)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl |
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