微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
PHA-793887是一种新型有效的CDK2，CDK5和CDK7抑制剂，IC50分别为8 nM，5 nM 和10 nM，作用于CDK2，5，和7比作用于CDK1，4，和9选择性高6倍以上。可在低浓度下靶向多种细胞周期蛋白依赖性激酶，并具有针对多种癌细胞的高活性。
Targets
| Target | Value |
|---|---|
| CDK5/p25 | IC50: 5nM |
| CDK2/CyclinA | IC50: 8nM |
| CDK2/CyclinE | IC50: 8nM |
| CDK7/CyclinH | IC50: 10nM |
| CDK1/CyclinB | IC50: 60nM |
| CDK4/CyclinD1 | IC50: 62nM |
| GSK-3β | IC50: 79nM |
| CDK9/CyclinT1 | IC50: 138nM |
| In vitro (25°C) | DMSO | 61 mg/mL (168.75 mM) | |
| Water | Insoluble | ||
| Ethanol | 61 mg/mL (168.75 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 14 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.66 mL | 138.31 mL | 276.63 mL |
| 0.5 mM | 5.53 mL | 27.66 mL | 55.33 mL |
| 1 mM | 2.77 mL | 13.83 mL | 27.66 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
*The above data is based on the productmolecular weight 361.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10716 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 361.5 |
| Formula | C19H31N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 718630-59-2 |
| Synonyms | PHA793887 |
| SMILES | CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
Flavopiridol (Alvocidib)
Flavopiridol（Alvocidib）是一种细胞周期蛋白依赖性激酶抑制剂，与ATP竞争性抑制CDK，包括CDK1， CDK2， CDK4和CDK…
AT7519 trifluoroacetate
AT7519 trifluoroacetate是CDK1、2、4、6和9的多CDK抑制剂，IC50为10-210 nM，对CDK3的效力较低，对CDK7的活性较低。
JNJ-7706621
JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂，IC50为9 nM/4 nM，并且在无细胞分析中对CDK1/2的选择性是CDK3/4/…
LEE011 (Ribociclib)
LEE011 (Ribociclib)是一种可口服的细胞周期蛋白依赖性激酶（CDK）抑制剂，靶向细胞周期蛋白D1/CDK4和细胞周期…
Kenpaullone
Kenpaullone是CDK1/细胞周期蛋白B（IC 50 = 400 nM），CDK2/细胞周期蛋白A（IC 50 = 680nM），CDK5（IC 50 = 850nM）的有效…
Keywords:购买 PHA-793887 | PHA-793887 供应商 | 订购 PHA-793887 | PHA-793887 价格 | PHA-793887 生产商 | 订单 PHA-793887 | PHA-793887 代理商 | 购买 718630-59-2| 718630-59-2 供应商 | 订购 718630-59-2 | 718630-59-2 价格 | 718630-59-2 生产商 | 订单 718630-59-2 | 718630-59-2 代理商|buy PHA-793887 | PHA-793887 Supplier | purchase PHA-793887 | PHA-793887 cost | PHA-793887 manufacturer | order PHA-793887 | PHA-793887 distributor | buy 718630-59-2| 718630-59-2 Supplier | purchase 718630-59-2 | 718630-59-2 cost | 718630-59-2 manufacturer | order 718630-59-2 | 718630-59-2 distributor