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PHA-848125 (Milciclib)

PHA-848125 (Milciclib)

目录号: A11047

CDK 抑制剂

PHA-848125 (Milciclib) Chemical Structure

CAS NO. 802539-81-7

PHA-848125 (Milciclib)是一种有效的，ATP竞争性CDK抑制剂，作用于CDK2，IC50为45 nM，作用于CDK2比作用于CDK1，2，4，5和7选择性高3倍以上。

库存：缺货

规格	价格
5 mg	￥ 1,400.00
10 mg	￥ 2,240.00
50 mg	￥ 5,950.00
100 mg	￥ 11,550.00
10mM * 1mL in DMSO	￥ 1,701.00

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生物活性

PHA-848125 (Milciclib)是一种有效的，ATP竞争性CDK抑制剂，作用于CDK2，IC50为45 nM，作用于CDK2比作用于CDK1，2，4，5和7选择性高3倍以上。

Targets

Target	Value
CDK2/CyclinA	IC50: 45nM
TrkA	IC50: 53nM
CDK7/CyclinH	IC50: 150nM
CDK4/CyclinD1	IC50: 160nM
CDK5/p35	IC50: 265nM
CDK2/CyclinE	IC50: 363nM
CDK1/CyclinB	IC50: 398nM

溶解度 *

In vitro (25°C)	DMSO	91 mg/mL (197.58 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.71 mL	108.55 mL	217.11 mL
0.5 mM	4.34 mL	21.71 mL	43.42 mL
1 mM	2.17 mL	10.86 mL	21.71 mL
5 mM	0.43 mL	2.17 mL	4.34 mL

*The above data is based on the productmolecular weight 460.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11047
作用机制	Inhibitor (抑制剂)
M. Wt	460.6
Formula	C25H32N8O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	802539-81-7
Synonyms	Milciclib, PHA848125
SMILES	CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C

产品资料

Download PHA-848125 (Milciclib) SD file

Products Specification Data Sheet

Safety Data Sheet (SDS)

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